Issue #65 Apocalypsis, or The Dragon in Her Cave

Apocalypsis, or The Dragon in Her Cave

Jimmie Durham

Issue #65
May 2015

Calypso is the leading technology platform for cross-asset trading,

Accounting, processing, and enterprise risk management.

Key words:

Cross asset









Necessarily hopeful verbosity.

Marco Koch, Luis Varela, Jae Geun Kim, Jung Dae Kim, Francisco Hernández-Nuño, Stephanie Simonds, Carlos Castorena, Claudia Vianna, Joel Elmquist, Yury Morozov, Pasko Rakic, Ingo Bechmann, Michael Cowley, Klara Szigeti-Buck, Marcelo Dietrich, Xiao-Bing Gao, Sabrina Diano & Tamas Horvath

Published an article in which they wrote that,

“Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC neurons. We show that chemical promotion of CB1R activity increases feeding, and notably, CB1R activation also promotes neuronal activity of POMC cells. This paradoxical increase in POMC activity was crucial for CB1R-induced feeding, because designer-receptors-exclusively-activated-by-designer-drugs (DREADD)-mediated inhibition of POMC neurons diminishes, whereas DREADD-mediated activation of POMC neurons enhances CB1R-driven feeding. The Pomc gene encodes both the anorexigenic peptide α-melanocyte-stimulating hormone, and the opioid peptide β-endorphin. CB1R activation selectively increases β-endorphin but not α-melanocyte-stimulating hormone release in the hypothalamus, and systemic or hypothalamic administration of the opioid receptor antagonist naloxone blocks acute CB1R-induced feeding. These processes involve mitochondrial adaptations that, when blocked, abolish CB1R-induced cellular responses and feeding. Together, these results uncover a previously unsuspected role of POMC neurons in the promotion of feeding by cannabinoids.”

Key words:



Another guy wrote that,

“Seasonal variation in box-office revenue is a statistical illusion:

If you release blockbusters in July and dogs in January,”

“Box-office” is almost certainly a key word there.

It surely may not refer to an office of boxes.

My feelings are indescribable.

Many of my feelings are indescribable.

The physiotherapist asked me to describe my pain on a scale of one to ten,

And if it was sharp, dull or pulsing.

It seems there may be no way

Of moaning eloquently

Yet many man-made musical instruments

Are capable

In the right hands.

Almost everything in the world is light-years away

From us.

But heavy,

Weightlessly insupportably heavy are the years

Passed and many splinters stay too near.

Every grain of sand

Finds its way to our salad bowls.

Return to Issue #65

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